CCR3, C-C motif chemokine receptor 3, 1232

N. diseases: 149; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE Therefore, we decided to analyze the regulation of CCR3 by IFN-gamma in asthmatics and to characterize the dependence of this process on immunoglobulin E (IgE) levels. 18849613 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE These results may suggest that eotaxin could be involved in the increased smooth muscle mass observed in asthmatics through the activation of CCR3. 16081847 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma. 26810221 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE In conclusions, through the modification of the expression of CCR-3 in peripheral blood leukocytes from atopic asthmatics, IFN-gamma could exert a beneficial effect in patients with asthma, regulating the migration of some inflammatory cells involved in the pathogenesis of the disease. 11699731 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE CCL26-targeted siRNA treatment of alveolar type II cells decreases expression of CCR3-binding chemokines and reduces eosinophil migration: implications in asthma therapy. 19203252 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.340 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.140 AlteredExpression disease LHGDN Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. 19017998 2008
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.130 AlteredExpression group BEFREE We have analysed the expression of CXCR3 and CCR5 as Th1-specific chemokine receptors, CCR3 as a marker for Th2 cells, CXCR4 (expressed on unprimed, naive T cells) and CCR2 (known to be involved in autoimmunity) on peripheral blood (PBL) and thyroid-derived lymphocytes (TL) using flow cytometry. 11966764 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.130 AlteredExpression disease BEFREE In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients. 12742662 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.130 AlteredExpression disease BEFREE Twenty remitting-relapsing MS patients with (n=10) and without (n=10) Gd(+) lesions entered the study. mRNA and surface expression of CD6 and CCR1, CCR2, CCR3 and CCR5 was measured by immunostaining and flow cytometry. 25242631 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE We then demonstrated in vitro that both CCL11 and its receptor, CCR3, were overexpressed and promoted the proliferation, migration and invasion of cancer cells. 27119233 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE CCR3 RNAi could effectively silence the expression of CCR3 mRNA and protein both <i>in vitro</i> and <i>in vivo</i>, thus promoting apoptosis of EOS and inhibiting its growth, migration and invasion. 28123492 2017
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 AlteredExpression disease BEFREE Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS. 12244149 2002
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 AlteredExpression disease BEFREE Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor, a co-receptor of HIV-1 infection. 11292016 2001
CUI: C0013595
Disease: Eczema
Eczema 		0.040 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE In addition, we screened tumor tissue sections of 219 patients and found that 28% (62 of 219) expressed the CCR3 receptor. 15814620 2005
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 AlteredExpression disease BEFREE Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. 9323208 1997
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 AlteredExpression disease BEFREE Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. 11056090 2000
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 AlteredExpression disease BEFREE The chemokine receptors CCR3 and CXCR4 are present and functional on SMC and are up-regulated in vascular diseases such as atherosclerosis. 16343467 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 AlteredExpression disease BEFREE The chemokine receptors CCR3 and CXCR4 are present and functional on SMC and are up-regulated in vascular diseases such as atherosclerosis. 16343467 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 AlteredExpression disease BEFREE Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. 11056090 2000
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.020 AlteredExpression disease BEFREE The eotaxin receptor CCR3 was expressed in both stromal and carcinoma cell populations of HL-like UCNT, this pattern being similar to the one observed in HL. 12792781 2003
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.020 AlteredExpression disease BEFREE CCR3 and CCR5 were highly expressed in T cells of HD involved but not of control lymph nodes. 11238088 2001
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.020 AlteredExpression group BEFREE Our results indicate that treatment of U373 cells with morphine significantly downregulated the gene expression of the beta chemokine, MIP-1 beta, while reciprocally upregulating the expression of its specific receptors, CCR3 and CCR5 suggesting that the capacity of mu-opioids to increase HIV-1 co-receptor expression may promote viral binding, trafficking of HIV-1-infected cells, and enhanced disease progression. 16022659 2005
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.020 AlteredExpression disease BEFREE Our data suggest that increased expression of CCR1 and CCR3 chemokine receptors may, in accord with various chemokines, contribute to the pathogenesis of nasal polyposis by facilitating increased migration and prolonged accumulation of inflammatory cells, e.g., eosinophils, in the inflammatory infiltrate of NP. 23054685 2013